Cysturol

Cysturol

5.880,00 рсд (sa PDV-om)

Cysturol je dodatak ishrani u obliku kapsula na bazi kvercetina, enzima bromelaina i papaina, uz prah ploda brusnice i biljne sastojke čistac, pasifloru i valerijanu. Ranije se na tržištu nalazio pod nazivom Cysta Q.

Namena: za mokraćnu bešiku.

Brend:

Kome je namenjen?​

Cysturol je namenjen odraslim osobama, posebno:

  • koje žele dopunu ishrani za mokraćnu bešiku
  • sa osetljivom bešikom ili čestim, hitnim mokrenjem, uz savet lekara
  • sa dijagnozom intersticijalnog cistitisa / sindroma bolne bešike, kao dopuna terapije po preporuci lekara

Ne preporučuje se osobama osetljivim na neki od sastojaka, trudnicama i dojiljama. Proizvod nije namenjen za decu.

 

Sastojci i njihova uloga

Bromelain i papain
Proteolitički enzimi iz ananasa (bromelain) i papaje (papain). Prema stručnom mišljenju, bromelain ima antiedematozno i antiinflamatorno delovanje, a papain je enzim sa proteolitičkom aktivnošću koji se koristi i kao pomoć pri varenju proteina[1][2]. Kvercetin se iz digestivnog trakta slabo resorbuje, a enzimi su dodati radi bolje iskoristljivosti kvercetina.

Brusnica
Plod američke brusnice (Vaccinium macrocarpon) bogat je vitaminima, mineralima I polifenolima sa antioksidativnim delovanjem. Tradicionalno se koristi kod tegoba mokraćnih puteva[1] .

Čistac, pasiflora i valerijana
Biljni sastojci koji se tradicionalno koriste: čistac (Stachys officinalis) u narodnoj medicini, a pasiflora (Passiflora incarnata) i koren valerijane (Valeriana officinalis) kod nemira i napetosti[1][3][4]. U Cysturolu su prisutni u malim količinama, ispod terapijskih doza.

Odrasle osobe: 1 kapsula dnevno sa čašom vode ili po preporuci lekara. Ne prekoračiti preporučenu dnevnu dozu.

Sastojak U 1 kapsuli
Kvercetin
u obliku kvercetin-dihidrata		 do 0,54 g
Bromelain (10:1, 80 GDU) i papain 24 mg
Prah ploda brusnice
Vaccinium macrocarpon		 10 mg
Prah lista čistaca
Stachys officinalis		 2 mg
Prah herbe pasiflore
Passiflora incarnata		 2 mg
Prah korena valerijane
Valeriana officinalis		 2 mg
Nutritivna referentna vrednost nije utvrđena. Neto masa kapsule 0,7 g; neto masa pakovanja 42 g.

Ostali sastojci: hipromeloza, biljna stearinska kiselina, mikrokristalna celuloza, silicijum-dioksid, magnezijum-stearat i kalcijum-karbonat.

Naučna podloga formulacije

Intersticijalni cistitis
Intersticijalni cistitis ili sindrom bolne bešike (IC/PBS) je hronično stanje čiji uzrok nije poznat. Javlja se češće kod žena. Tegobe uključuju bol u predelu mokraćne bešike, donjem delu trbuha i iza pubične kosti, često i hitno mokrenje i nelagodnost u toku seksualnog odnosa. Može biti praćeno smanjenjem kapaciteta bešike i narušenim kvalitetom života, a lečenje je dugotrajno i često zahteva saradnju ginekologa i urologa[8][9][10].

Studije sa formulacijom Cysta Q (raniji naziv Cysturola)
Katske F, Shoskes DA, Sender M, Poliakin R, Gagliano K, Rajfer J. Treatment of interstitial cystitis with a quercetin supplement. Tech Urol. 2001; 7(1): 44–46[5]

Graminex za SUNN BIOLABS LLC, 402 West Broadway, suite 400, San Diego, CA 92101, SAD. Zemlja porekla: SAD.
Uvoznik i distributer: Vidapharm d.o.o., Gospodara Vučića 173, Beograd, Republika Srbija, www.vidapharm.rs

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2. Repchinsky C, editor. Compendium of Pharmaceuticals and Specialties. The Canadian Drug Reference for Health Professionals. Ottawa (ON): Canadian Pharmacists Association; 2008
3. Zembron-Lacny A, Slowinska-Lisowska M, Szygula Z, Witkowski K, Szyszka K. The comparison of antioxidant and hematological properties of N-acetylcysteine and a-lipoic acid in physically active males. Physiological Research 2009;58:855 861
4. Zembron-Lacny A, Szyszka K, Szygula Z. Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise by evaluation of pro-antioxidant ratio. The Journal of Physiological Sciences 2007;57(6):343-348.
5. Virmani A, Binienda Z. Role of carnitine esters in brain neuropathology. Mol Aspects Med 2004; 25: 533-49
6. Virmani A. et al. Eds. E.Y. Adashi and S. Mancuso. Sereno Symposium Publication. Raven Press. 73, 291-96, 1991
7. Mansour G. et al. L-carnitine supplementation reduces oocyte cytoskeleton damage and embryo apoptosis induced by incubation in peritoneal fluid from patients with endometriosis. Fertil Steril 2009; 91 (Suppl. 5): 2079-2086
8. Krsmanovic L.Z. et al. Actions of acetyl-L-carnitine on the hypothalamo-pituitary-gonadal system in female rats. J Steroid Biochem Mol Biol. 1992; 43 (4): 351-8
9. Salehpour S. et al. N-Acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome J Obstet Gynaecol Res 2012; 38 ovulation in infertile patients with polycystic ovary syndrome. J. Obstet. Gynaecol. Res. 2012; 38 (9): 1182-1186
10. Fitz V, Graca S, Mahalingaiah S, Liu J, Lai L, Butt A, Armour M, Rao V, Naidoo D, Maunder A. Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines. J Clin Endocrinol Metab. 2024; 109(6): 1630-1655. doi:10.1210/clinem/dgad762 (ispravka: J Clin Endocrinol Metab. 2024; 109(12): e2365, doi:10.1210/clinem/dgae588)
11. Virmani MA, Vitullo P, Cossetti C. Effect of specific nutrients on ovulation, oocytes development, gene expression and coupling success in mice. 23èmes Journées de la Fédération Française d’Étude de la Reproduction (FFER), Lyon, 12-14 septembre 2018 (poster).
12. Genazzani A, Meczekalski B. Supplement containing acetyl-L-carnitine, L-carnitine and vital nutrients modulates neuroendocrine and reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea (FHA). International Society of Gynecological Endocrinology (ISGE), Florence, March 2016; ESHRE, Helsinki, July 2016 (poster).
13. Samimi M, Jamilian M, Afshar Ebrahimi F, Rahimi M, Tajbakhsh B, Asemi Z. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clin Endocrinol (Oxf). 2016; 84: 851-857. doi:10.1111/cen.13003
14. Yazbeck C. et al. Role of carnitines supplementation (Proxeed Women 400 Folic, PWM007A) on IVF outcome in women suffering from endometriosis. Klinička studija, Francuska, 2019-2021.
15. Genazzani A, Meczekalski B. Perimenopause and glucose metabolism, Phase 3 (Proxeed Women, PXW008A). Klinička studija, Italija, 2020-2021.
16. Artini P, Tatone C. Effects of Proxeed Women Inositol in PCOS women (Protocol PXW-003A). Klinička i pretklinička studija, Italija, 2018-2021.